منابع مشابه
The Human Serum Metabolome
Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the metabolomics community to develop centralized metabolite reference resources for certain clinically important biofluids, such as cerebrospinal fluid, urine and blood. As part of an ongoing effort to...
متن کاملLoss-of-function variants influence the human serum metabolome
The metabolome is a collection of small molecules resulting from multiple cellular and biological processes that can act as biomarkers of disease, and African-Americans exhibit high levels of genetic diversity. Exome sequencing of a sample of deeply phenotyped African-Americans allowed us to analyze the effects of annotated loss-of-function (LoF) mutations on 308 serum metabolites measured by u...
متن کاملGenetic Determinants Influencing Human Serum Metabolome among African Americans
Phenotypes proximal to gene action generally reflect larger genetic effect sizes than those that are distant. The human metabolome, a result of multiple cellular and biological processes, are functional intermediate phenotypes proximal to gene action. Here, we present a genome-wide association study of 308 untargeted metabolite levels among African Americans from the Atherosclerosis Risk in Com...
متن کاملThe Human Metabolome
The human metabolome is best understood by analogy to the human genome, i.e. where the human genome is the set of all genes in a human, the human metabolome is the set of all metabolites in a human. Whereas the science of genomics is based upon a genome, the science of metabolomics is grounded in a metabolome. To continue the genome/metabolome analogy, it should be apparent that any published h...
متن کاملThe human circadian metabolome.
The circadian clock orchestrates many aspects of human physiology, and disruption of this clock has been implicated in various pathologies, ranging from cancer to metabolic syndrome and diabetes. Although there is evidence that metabolism and the circadian clockwork are intimately linked on a transcriptional level, whether these effects are directly under clock control or are mediated by the re...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2011
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0016957